For scientifc references, it is best to refer to the following databases:
- In English from the USA, US National Library of Medicine (keyword “Cannabidiol”)
- In French, Association International pour le Cannabis Médical
One of the most important piece of work was done by the British Pharmacological Society, in 2012: important new clinical applications for this phytocannabinoid. The A-Z research by illness, done by CBD Crew .org is a great way to look at research by topic: stress, sleep disorders, skin conditions, pains, migraine, inlfamation, diabetes, stomac problems, anxiety, …
The role of Endocannabinoid: studies on Endocrine system and hormones:
- Endocannabinoid system participates in neuroendocrine control of homeostasis (PubMed)
- The emerging role of the endocannabinoid system in endocrine regulation and energy balance(PubMed)
- Endocannabinoids in endocrine and related tumours (PubMed)
- Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas (PubMed)
- The role of the endocannabinoid system in the neuroendocrine regulation of energy balance (PubMed)
- Effect of cannabidiol on plasma prolactin, growth hormone and cortisol in human volunteers (PubMed)
The role of Cannabidiol: studies on anti-anxiolytic (Anxiety & Stress ):
- Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug (PubMed)
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
- Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (PubMed)
- Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder(PubMed)
- Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (PubMed)
- Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)
- The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors (PubMed)
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system (PubMed)
- Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence (PubMed)
more specifically on stress:
- Endogenous cannabinoid signaling is essential for stress adaptation (PubMed)
- Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders (PubMed)
- Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output (PubMed)
- Neuromodulators, stress and plasticity: a role for endocannabinoid signalling (PubMed)
- Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress (PubMed)
- Endocannabinoids and stress (PubMed)
- Stress regulates endocannabinoid-CB1 receptor signaling (PubMed)
- Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus (Pub Med)
- Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance (PubMed)
- Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression (PubMed)
- Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory (PubMed)
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system (PubMed)
- Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid (PubMed)
The role of Cannabidiol: the effects of CBD on metabolism & body fat:
- The impact of marijuana use on glucose, insulin, and insulin resistance among US adults (American Journal of Medicine)
- The potential use of cannabidiol in the therapy of metabolic syndrome (PubMed)
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes (PubMed)
- Cannabinol and cannabidiol exert opposing effects on rat feeding patterns (PubMed)
- Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss? (PubMed)
- The endocannabinoid system in obesity and type 2 diabetes (PubMed)
- Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk (PubMed)
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes (PubMed)
The role of Cannabidiol: the effects of CBD on sleep
- The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent (PubMed)
- Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine (PubMed)
- Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats (PubMed)
- Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults (PubMed)
- Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats (PubMed)
- Endocannabinoid modulation of cortical up-states and NREM sleep (PubMed)
- Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat (PubMed)
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